Pharmacodynamics and pharmacokinetics
Aerosol Para Plus is a combination drug used to treat head lice (infestation of the scalp with lice
The pharmacological effectiveness of the drug is manifested due to the insecticidal effect of its active ingredients, where malathion acts as an organophosphorus insecticide , permethrin is a neurotoxic anti-insect poison , and piperonyl butoxide increases the effect of the latter.
Composition of the drug Para Plus
The drug is produced in the form of an aerosol in a 116 g container. with a sprayer. The liquid is presented in the form of an oily solution with a specific odor, not very strong. The solution is transparent, with a slightly yellowish tint. The spray contains three active substances with a powerful insecticidal effect:
- Permethrin is a substance that has a negative effect on the nervous system of insects.
- Malathion is an organophosphorus insecticide that affects the nerve structures of lice. The main advantage of this substance is its ability to influence not only adult insects and larvae, but also their eggs, called nits. Another, more well-known name for this substance is karbofos.
- Piperonyl butoxide helps enhance the effects of permethrin, causing toxic effects on the nervous system, and also destroys the enzyme system of lice. It has a contact action, i.e. can act not only through the respiratory tract and intestines of insects, but also through their chitinous shell - it is enough for the drug to get on the insect’s body.
The composition contains isododecane and tetrafluoroethane (HFA propellant) as excipients.
Aerosol Para Plus, instructions for use
Instructions for use of Para Plus assume exclusively external use of the drug.
Using short-term pressure on the sprayer, apply the drug evenly over the entire length of the hair and scalp . Without covering your head, wait 10 minutes, after which you thoroughly wash off the aerosol using regular shampoo. get rid of dead insects and nits remaining on your hair and scalp using a frequent comb.
Also, to prevent re-infection, it is necessary to treat all the patient’s personal belongings (hats, pillows, collars, towels, etc.) with the drug.
In case of severe infection, it may be necessary to re-use the drug, which is carried out after 7 days.
Reviews
The effectiveness of the drug is confirmed by numerous reviews. Let's list some of them.
- Victoria, 21 years old. During my studies, I did an internship at a children's camp, and it was there that I picked up lice from the children. This caused me to panic. I have long hair, and I didn’t want to part with it. The nurse recommended Para Plus. The drug helped get rid of the problem quickly and effectively - the parasites disappeared in just one application.
- Andrey, 33 years old. My daughter brought lice from kindergarten. At first they were confused and didn’t know what to do. Para Plus was recommended at the pharmacy, since this drug is approved for children. It is easy to apply because it is oil-based, does not tangle the hair and makes it possible to comb out parasites without any problems.
- Elena, 40 years old. I am a pharmacist with quite a lot of experience, and during my work I have come across many anti-pediculosis drugs, both domestic and imported. I can say that Para Plus is one of the best remedies. The drug has very few side reactions and contraindications, is not that expensive, and this price is justified.
- Valeria, 31 years old .
I never thought that this could happen to me. I picked up lice at a hairdresser, where I went for quite a long time - apparently, the unscrupulous hairdresser did not disinfect the tool. I was shocked, even at the pharmacy I was ashamed to ask to recommend the drug. As a result, the seller recommended Para Plus. I thought that the process of using the product would be difficult, but this is not the case at all. I just applied the aerosol for 10 minutes, then washed it off and combed out the parasites. I repeated the procedure again to consolidate the effect. Thus, I was able to completely forget about this terrible problem.
Para Plus is one of the best remedies against lice. The drug is effective and easy to use, it acts quickly and has a minimum of contraindications. Before using the aerosol, it is important to study the instructions for it.
Analogs
Level 4 ATX code matches: Medifox
Veda 2
Hygia
Permethrin ointment
Spregal
Pedilin
Nittifor
- Pedilin;
- Nittifor;
- Pedex;
- Spray-Pax;
- Permethrin;
- Spregal;
- Ithax;
- Permin;
- Medifox;
- Hygia.
Release form "Para Plus"
"Para Plus" is an oily liquid with a slight odor. Sold in a bottle equipped with a spray cap.
1 package contains 116 g, this amount is enough for 2 times to disinfect long hair from lice; with short hair, more procedures can be done.
The cylinder is packed in a cardboard box and comes with an insert with instructions.
The drug can be purchased at a pharmacy at an affordable price . This product is manufactured by a well-known French pharmacological company.
Reviews about Para Plus
Judging by the number of comments, the problem of treating head lice remains quite acute, and pharmacies often recommend Para Plus aerosol to solve it, the reviews of which are quite varied from patients themselves.
For some people, this drug completely helped get rid of this unpleasant illness in all cases, for others it did not bring the expected relief, and for others it caused adverse reactions in the form of skin burns and damaged hair .
It is worth noting that side effects most often occurred in people who used the aerosol incorrectly (for longer than according to instructions) or in patients with hypersensitivity to its ingredients.
Also, the insufficient effectiveness of the drug may be associated with the treatment of only the patient’s head, without disinfecting his personal belongings and household items, through which re-infection can occur.
Based on the above, we can assume that if the drug is used correctly and all the doctor’s recommendations are followed, Para Plus will turn out to be a fairly effective drug and in most cases will help in the fight against head lice .
Contraindications
Before using the product, it is important to read the instructions. In accordance with it, contraindications for its use include:
- age under 2.5 years;
- presence of bronchial asthma;
- hypersensitivity to substances in the composition.
Do not use the drug if there are wounds, abrasions, burns or other damage to the scalp. Such a component of the composition as piperonyl butoxide is quite toxic, and if it enters the circulatory system, it can spread throughout the body and cause partial paralysis.
Price Para Plus, where to buy
In Russian pharmacies, the price of Para Plus aerosol ranges from 400-500 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in KazakhstanKazakhstan
LuxPharma* special offer
- Para Plus (analogue of Kwell-R shampoo 60 ml)
RUB 1,950 order
show more
How to use Para Plus
The spray is easy to use, but it is important to remember that all insecticidal products require a responsible approach and following the instructions.
- There is no need to wash your hair before use, as the product is intended for use only on dry hair. The product is sprayed from a distance of 3-5 cm onto the scalp, without missing a single area, and then, sequentially treating strand by strand, over the entire length of the hair.
- The amount of product required for thorough treatment depends on hair length and thickness. For very long and thick hair, it may well take the entire can of aerosol, but on average the package is enough for two treatments for medium-length hair and several treatments for short hair.
- After treatment, you should not cover your head, as this creates a greenhouse effect and the drug can have a negative effect on the scalp.
- Leave the product on for 10 minutes, then wash your hair using shampoo. The solution is washed off without any problems. To remove dead parasites and nits, you need to comb them out well. To do this, use fine head lice combs.
- For pubic lice, apply the product to the pubis and hair in the groin area, avoiding contact of the drug on the mucous membranes of the genital organs, hold for 10 minutes, rinse with soap or shower gel.
- If the infection is severe, then the treatment must be repeated after a week, since a very large amount may leave a certain number of live nits on the hair. Within a week, larvae will hatch from them, which will be destroyed by repeated use of the spray. This way you will be able to get rid of all parasites.
Composition and principle of action
The main components of Para Plus are:
- permethrin;
- piperonyl butoxide;
- malathion
HFA 134a propellant and isododecane are used as additional substances. The combined action of the active components ensures the high effectiveness of the drug Para Plus, and parasites do not become accustomed to these substances.
The action of the product is based on blocking nerve impulses in blood-sucking insects, which ultimately causes paralysis and death. At the same time, small aerosol particles are able to penetrate inside the shell of nits, destroying them too.
Basic data
“Pair Plus” for lice and nits is available in the form of a spray contained in sealed metal containers. It is a clear oily liquid. The main active ingredients are three insecticides , which are strong individually, but together create a powerful synergistic effect that enhances the effect of each component.
Let's look at them in more detail:
- Permethrin
This is a well-known insecticide, which is the main one in most pharmaceutical products. It has proven effective against lice as well as other small insects.
The main principle of its action is penetration through the chitin of an insect and damage to its nervous system, provoking paralysis of internal organs and breathing in particular. But permethrin by itself is not very effective against nits.
- Peperonyl butoxide
This insecticide enhances the effect of pyrethroids, which include permethrin.
The enhancing effect manifests itself in accelerating the time of onset of paralysis. It is especially toxic to the digestive system.
- Malathion (karbafos)
This poison is absorbed by the digestive system of insects and turns into malokoson, which is fatally toxic to them, affecting their nervous system.
Together, these substances not only kill not only lice, but also their eggs - nits. This is achieved due to the high penetrating effect; poisons enter the body not only through breathing, but also through the insect’s shell. Therefore, they attack eggs, bypassing their external protection.
Another advantage of “Pair Plus” is that it is harmless to humans . Its constituent substances are practically non-toxic to humans when used externally.
